Surgery, radiation therapy, and chemotherapy can be used alone or together to treat AA. Treatment usually begins with surgery to reduce the size of the tumor. Surgery is usually followed by radiation therapy and chemotherapy with temozolomide (the generic drug name for Temodar®). The type and sequence of therapies may be different for each patient, depending on each unique situation.
What is eflornithine?
Our product candidate, eflornithine, is a novel cytostatic (growth inhibiting) agent, which we are developing for the potential treatment of patients with anaplastic astrocytoma (AA). Eflornithine is a molecule that targets a key enzyme called ornithine decarboxylase. Ornithine decarboxylase plays a role in cancer cell growth.
In research studies of humans and animals, eflornithine has been shown to delay or stop the growth of brain cancer and other kinds of cancer cells.
Eflornithine is an investigational product, meaning it has not been proven to be safe and effective for this use and is not licensed by the US Food and Drug Administration or any other government agency. An investigational product can only be administered in a research study. Eflornithine oral investigational medicine has not been proven to be safe and effective in treating patients with recurrent anaplastic astrocytoma (or rAA). Eflornithine oral investigational medicine may only be administered to patients who participate in a research study. Eflornithine oral investigational medicine is not licensed for the treatment of rAA in the United States or any other country.
What is lomustine?
Lomustine is the generic drug name for CCNU (also called CeeNU® or Gleostine®), a chemotherapy drug that is used to treat certain types of cancers, including brain cancers. It is often used to treat patients with rAA in clinical practice. Lomustine is not specifically licensed for the treatment of rAA in the United States or in any other country.
Lomustine belongs to the class of chemotherapy drugs called alkylating agents. Alkylating agents affect the DNA in cells and delay or stop cell growth. Lomustine capsules are taken by mouth once every 6 weeks